Fusion gene depletion eliminates stemness and induces bidirectional differentiation of acute myeloid leukemia.

Extreme limiting dilution analysis uncovered a highly significant ( P < .001; likelihood ratio test) fivefold reduced frequency of leukemia-restoring cells (LRCs) after RUNX1 :: RUNX1T1 knockdown, whereas mismatch control cells showed no significant difference in LRC frequencies compared to mock-treated cells ( Figure 7 G).

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