Barely Significant
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Global, regional, and national burden of brain and other central nervous system cancers from 1990 to 2021, and projections to 2035: a systematic analysis for the global burden of disease study 2021.

Int J Surg · 2026 · PMC12825802 · PMID 41247817

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an increasing trendno p-value reported
Indeed, with advancing age, the patients with CNS cancers showed an increasing trend in prevalence, incidence and mortality rates, particularly in the elderly.

also in 63,971 other papers

a decreasing trendno p-value reported
Nevertheless, 19 countries showed a decreasing trend in ASRs of incidence, including some developed countries (the USA, Australia, and Sweden).

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.