Declining incidence of Parkinson's disease in Israel (2002-2021).

Trend by age groups Throughout the entire study period, all age groups showed a decreasing trend in AAIR, in which the steepest decline belonged to the oldest age group, 85 + years (AAPC − 7.7, 95% CI: − 8.5 to − 7.1, p < 0.001), while the lowest rates were calculated for the 40- to 44-year age group (AAPC–− 1.8, 95% CI: − 4.3 to − 0.8, p = 0.188) (Fig. 1 ).

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Local drifts with net drift, characterizing annual percentage changes in PD-onset ages, were highly significant in both sexes, thus rejecting the null hypothesis.

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