Metabolomic analysis identifies alterations of amino acids in the tears and plasma of patients with dry eye disease with ocular pain.

After applying FDR correction, plasma 1-MEHIS continued to demonstrate a highly significant association with DED with ocular pain ( q -value < 0.001), indicating superior diagnostic potential. 3.6 The correlation between MET in tear fluid, 1-MEHIS in plasma, other clinical variables, and the DED with ocular pain The results of the correlation analysis ( Table 6 ) showed that the MET in tear fluid exhibited negative correlations with CNFD ( r = −0.430, p < 0.05), CNBD ( r = −0.379, p < 0.05), CNFL ( r = −0.399, p < 0.05), CTBD ( r = −0.345, p < 0.05) and CNFA ( r = −0.312, p < 0.05), while positively correlated with age ( r = 0.301, p < 0.05).

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