an increasing trendP < .001
CV-A6 is the predominant pathogen of atypical skin lesions In recent years, with the rising CV-A6-related HFMD prevalence, the incidence of atypical skin lesions has also shown an increasing trend ( Χ 2 = 3053.287, P < .001) until culminating in a peak incidence rate in 2023 ( Supplementary Table S8 , Supplementary Fig.