Barely Significant
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Coxsackievirus A6 was the predominant pathogen of hand, foot, and mouth disease with frequent recombination and mutations in Shandong Province, 2023.

Virus Evol · 2026 · PMC12828700 · PMID 41583791

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The sentences

an increasing trendP < .001actually significant
CV-A6 is the predominant pathogen of atypical skin lesions In recent years, with the rising CV-A6-related HFMD prevalence, the incidence of atypical skin lesions has also shown an increasing trend ( Χ 2 = 3053.287, P < .001) until culminating in a peak incidence rate in 2023 ( Supplementary Table S8 , Supplementary Fig.

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