IgA defects in CVID lead to bacterial translocation, increased serum γ-interferon, and BAFF.

This is illustrated for this cohort, examining the 55 CVID subjects with inflammatory complications (Group 2) as compared to 59 other CVID subjects without these medical issues (Group 1) or 21 normal controls, showing highly significant differences between the patient groups (P = 0.0001.) Fig. 1 A .

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