Utility and clinical effectiveness of liquid biopsy-based DNA methylation testing in early tumor screening and diagnosis, emphasizing older adult populations: a systematic review and meta-analysis.

Front Oncol · 2025 · PMC12832247 · PMID 41602411

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP < 0.00001actually significant

In blood-based samples (4 studies), the pooled log odds was 0.99 (SE = 0.23), with no heterogeneity (I2 = 0%) and a highly significant overall effect (Z = 7.29, P < 0.00001).

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