Lipid and immune dysregulation and risk of metabolic disorders after HCV clearance in HIV/HCV-coinfected participants with cACLD: a retrospective study.

Front Immunol · 2025 · PMC12833009 · PMID 41601646

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hedged sentences

0.0100

closest p · 0.2× alpha

0.0750

boldest claim

The sentences

highly significantp-value <0.010actually significant

To further illustrate these differences, the intensity distributions of the most highly significant lipid species (p-value <0.010, q-value <0.100) are presented in Supplementary Figure 2 .

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a marginal trendp-value =0.075so close (0.05 < p ≤ 0.1)

Unlike the lipidomic profile, none of the immune markers reached statistical significance (p-value <0.050, q-value <0.200), although TNF-RI showed a marginal trend (HR = 3.83; p-value =0.075, q-value =0.286).

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close to significanceno p-value reported

Besides, several SM showed p-values close to significance, suggesting a possible coordinated dysregulation of the sphingolipid pathway.

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