Simultaneous single-cell proteomics and epigenetic analysis of histone deacetylase inhibition in human cells.

Similarly, four peptides were observed with a combination of acetylations affecting Histone H4 on K9, K13 and K17 and are, as a group, found to be highly significantly increased following drug treatment.

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However, I do observe a somewhat significant increase in total H4 protein abundance following mocetinostat treatment (Fig. 2D, E ).

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