Systematic discovery of new recognition peptides mediating protein interaction networks.

PLoS Biol · 2005 · PMC1283537 · PMID 16279839

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highly significantno p-value reported

For example, the SH3-binding pattern RxPxxP readily occurs in about one out of 20 randomly selected proteins, but its occurrence in seven sequences in a set of nine becomes highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.