Subsequent to this analysis, genes that manifest independent associations are considered jointly significant, whereas those that no longer demonstrate significance are classified as marginally significant. 2.9 MR Utilizing candidate genes identified through TWAS analyses, we conducted an MR analysis with the ‘TwoSampleMR’ R package (version 0.6.8) to investigate the potential causal associations between these genes and longevity.
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Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness.
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