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Longitudinal associations of chronic pain severity trajectories and number of pain site trajectories with risk of limitations in ability in daily activities: Evidence from two 10-year prospective cohort studies.

J Nutr Health Aging · 2026 · PMC12835589 · PMID 41544571

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an increasing trendno p-value reported
This trajectory requires the pain intensity to show an increasing trend over four cycles and to span at least three pain levels to ensure the characteristic of pain worsening.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.