At endpoint, both groups reported improvement on the PG-CGI, although the improvement for fluvoxamine did not quite reach statistical significance (p < 0.08 for fluvoxamine; p < 0.01 for topiramate); there were no statistically significant differences between the 2 groups.
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Comorbidity issues in the pharmacological treatment of Pathological Gambling: a critical review.
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This study, deliberately designed to evaluate the effectiveness of a mood stabilizer in pathological gamblers with comorbid bipolar spectrum features confirms previous reports of the effectiveness of these compounds in PG, and suggests that there may be significant advantages in subtyping pathological gamblers.