Rectal In Situ Thermosensitive Gel Loaded with Agomelatine-Silver Nanoparticles: Formulation and Characterization.

The release profile of AG shows a decreasing trend as both P188 and HPMC K15M percent increase ( Figure 8 ).

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The significant effect of P188 on GT is corroborated by the ANOVA results, where the P188 term (A) shows a highly significant F-value ( Figure 6 and Figure 7 and Table 1 ), indicating a strong influence on GT.

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