Reintervention for Failed Aortic Bioprostheses: Distinct Patient Profiles for Redo Surgery and Valve-in-Valve TAVR in an All-Comers Cohort.

J Clin Med · 2026 · PMC12842112 · PMID 41598413

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0560

boldest claim

The sentences

borderline significancep = 0.052so close (0.05 < p ≤ 0.1)

Endocarditis remained associated with mortality at borderline significance (HR 4.32, 95% CI 0.99–18.86; p = 0.052; see Figure 2 ), and NYHA IV was similarly borderline (HR 4.86, 95% CI 0.98–24.14; p = 0.053; see Figure 3 ).

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narrowly missed significancep = 0.056so close (0.05 < p ≤ 0.1)

In the redo-SAVR cohort, 47.6% required concomitant procedures and ~26% presented with endocarditis, contributing to a higher EuroSCORE II that narrowly missed significance ( p = 0.056) [ 14 ].

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