Cytotoxic Effects of a Triorganotin Derivative on HTLV-1-Infected Cells at Different Immortalization/Transformation Stages In Vitro.

Data obtained from three independent experiments show a significant and a highly significant increase in PB2/IL-2 cells with altered nuclear morphology following treatment with 10 μM TBT and 20 μM TBT, respectively, in comparison with control cells.

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In parallel, the curve of red fluorescent cells undergoing lytic cell death also shows an increasing trend, even if slighter than that observed for green fluorescent cells, from the beginning of the observational time in culture.

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