Oral GAD65-<i>L. lactis</i> Vaccine Halts Diabetes Progression in NOD Mice by Orchestrating Gut Microbiota-Metabolite Crosstalk and Fostering Intestinal Immunoregulation.

Microorganisms · 2026 · PMC12844348 · PMID 41597694

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Furthermore, it mainly inhibited LPLs CD8 + T lymphocytes and the proliferation of mature DCs, while showing an increasing trend in IL-10-secreting naive DCs, which subsequently induced the proliferation of Tregs; concurrently, elevated levels of TGF-β were detected, indicating that this vaccine induced a tolerance-promoting environment in the intestine.

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