Hitting the Target: Model-Informed Precision Dosing of Tobramycin in Pediatric Patients with Cystic Fibrosis.

In comparison, applying the same AUC 24,ss target to the pre-MIPD period ( Figure 1 ), achievement was lower than during the post-MIPD period at TDM 1 ( p < 0.05) and TDM 3 (< 0.05) with a nonsignificant trend toward lower target achievement at TDM 2 ( p = 0.086).

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