Barely Significant
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Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis.

Pharmaceuticals (Basel) · 2026 · PMC12844662 · PMID 41599725

Europe PMCDOI
1
hedged sentence
0.0010
closest p · 0.0× alpha
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boldest claim

The sentences

highly significantp < 0.001actually significant
Accordingly, age distribution differences were highly significant ( p < 0.001), with isotretinoin over-represented in adolescents and topical retinoids more frequent in children and older adults, potentially reflecting off-label or non-acne use of topical agents.

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