Unraveling Cannabidiol's Bidirectional Regulation of Melatonin Pharmacokinetics via PEPT1/CYP1A2: Mechanistic Insights and Quantitative Projections.

Pharmaceuticals (Basel) · 2025 · PMC12845078 · PMID 41599679

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highly significantno p-value reported

A p -value < 0.05 was considered statistically significant, and p < 0.01 was regarded as statistically highly significant.

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a decreasing trendno p-value reported

With the increase in the dose of co-administered oral CBD, the C max of MT gradually decreased, and the exposure in the absorption phase, AUC (0–1h) , showed a decreasing trend.

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