Host-Filtered Blood Nucleic Acids for Pathogen Detection: Shared Background, Sparse Signal, and Methodological Limits.

In contrast, the TB cohort was much more sensitive to host-filtering stringency: both TB-negative and TB-positive groups exhibited markedly higher non-host fractions under the relaxed mode than under the strict mode, with highly significant within-sample differences ( p < 0.0001; Figure 2 A).

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