Structure-Guided Engineering of Protein VP2 from Epizootic Hemorrhagic Disease Virus Maximizes Production and Confers Complete Protection as Subunit Vaccine.

Vaccines (Basel) · 2025 · PMC12846072 · PMID 41600923

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highly significantno p-value reported

Aside from the antigenicity of the recombinant vaccine candidate based on a modified protein VP2 of EHDV-8, a highly significant aspect of this work is the generation of a DIVA-compatible vaccine candidate through a more efficient production process, yielding a stable antigen able to induce protective immunity comparable to that of currently licensed vaccines.

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