Redefining the modern paradigm of vasopressor therapy for vasodilatory shock.

16 During hyperdynamic sepsis, noradrenaline infusion increased renal blood flow and medullary blood flow but only induced a nonsignificant trend towards improved cortical blood flow. 17 These changes were accompanied by increased urine output. 4.2 Adrenaline The effect of adrenaline was studied in conscious sheep during hyperdynamic sepsis. 18 Adrenaline infusion (0.4 μg/kg/min) increased mean arterial pressure and cardiac output and decreased heart rate.

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