Differences in the area under the curve were no longer significant between any treatment groups, although a nonsignificant trend toward lower values was detected in the sG WT treatment group/subsequent infection with RSV group, indicating that the sG effect was almost completely compensated for by NLRP3 blockade.
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The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis.
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