SOLVE: A structured orthogonal latent variable framework for disentangling confounding in matrix data.

Biol Methods Protoc · 2026 · PMC12848822 · PMID 41613603

Europe PMC DOI

hedged sentence

0.0004

closest p · 0.0× alpha

0.0004

boldest claim

The sentences

highly significantP = 4e-4actually significant

For example, SOLVE identified a highly significant association between GRB7 expression and sensitivity to the drug Erlotinib ( P = 4e-4 for SOLVE vs. .98 for CATE).

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