Effect of prophylactic antibiotics on days of antibiotic spectrum coverage in comatose post-cardiac arrest patients: a secondary analysis of PROTECT.

JAC Antimicrob Resist · 2026 · PMC12848830 · PMID 41614001

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an overall trendno p-value reported

8 , 10–16 Despite the different ways in which antibiotic use outcomes were measured, there was an overall trend in PROTECT, ANTHARTIC and PROPHY-VAP supporting antibiotic prophylaxis as a strategy to reduce subsequent open-label antibiotic use broadly in critically ill brain-injured patients.

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