SEER (Surveillance, Epidemiology, and End Results) database, there was an increasing trend of EAC from 1973 to 2009, of .4 to 2.58 cases per 100,000. 4 An updated review of the SEER database showed that EAC rates increased by >5% annually from 1992 to 2000 before stabilizing at an annual percentage change of .22% (95% confidence interval [CI], −.16 to .60) between 2000 and 2019.
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Incidence rates of Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis.
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