Comprehensive benchmarking of methods for mutation calling in circulating tumor DNA.

Nat Commun · 2025 · PMC12852940 · PMID 41407694

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 10−68actually significant

The overlaps with plasma were 47 (T1∩plasma) and 54 (M1∩plasma), both highly significant after Bonferroni correction (Fisher’s exact test p < 10−68 and p < 10−74; Supplementary Fig. 2a ), supporting the reliability of the plasma-derived ground truth.

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