Barely Significant
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Pilot-Scale Continuous Flow Synthesis of Capsaicinoids and Their Formulation with Cyclodextrins.

ACS Omega · 2026 · PMC12854497 · PMID 41626505

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highly significantno p-value reported
Therefore, while free capsaicinoids are restricted to the low μg/mL range in water, their CD inclusion complexes reach the milligram/milliliter range, a solubility level that is pharmaceutically and technologically highly significant.

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