Prospective Cohort Study of Obinutuzumab in Rituximab-Resistant Primary Membranous Nephropathy.

LLM and Generalized LMM After adjusting for temporal trends in biomarkers and within-subject correlations by using LMM and generalized LMM, we found that changes over time in 24-hour proteinuria, serum albumin, and serum total protein levels ( Figure 2 ); albumin and IgG fractional clearances ( Figure 3 ); and total serum IgG levels ( Figure 4 ), total and low-density lipoprotein cholesterol serum levels ( Supplementary Figure S4 ); and anti-PLA 2 R antibody titer ( Figure 5 ) were all highly significant in both cohorts.

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