Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2.

J Lipid Res · 2026 · PMC12859765 · PMID 41478358

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a decreasing trendno p-value reported

The amount of PC with C26:0 moiety, such as PC 26:0/18:1, was significantly reduced in two lines of X-ALD fibroblasts (X-ALD #2 and #3) expressing LPLAT10 guide RNA, whereas a decreasing trend was observed in the remaining line (X-ALD #1) ( Fig. 2 A, Supplemental Table S9 ).

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