This ZT4-specific effect distinguished activation of GHSR-expressing SCN neurons from activation of GHSR-expressing ARC neurons: food intake was increased in “misses/ARC” following CNO at all four time points; this increase was 530% at ZT4 ( Figures 1O – 1R and Table S4 ; 0.05 ≤ p < 0.1 [indicating a statistical trend] for three time points).
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Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons.
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