Eye involvement in a series of 94 young patients with congenital ichthyosis: Importance of early ophthalmological referral.

In multivariate modelling, EDD type, but not severity, remained associated with ocular involvement, while age showed a positive trend toward increasing risk over time ( Table II ) Causal inference analysis demonstrated a stepwise progression of eye disease: age-related MGD led to evaporative DED, which triggered conjunctival inflammation and keratopathy.

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