Global disease and economic burden of main mycobacterial infections in the working-age population from 1990 to 2021 with a forecast to 2045.

Individuals over 35 years of age were most affected by the DALYs from leprosy, which has an overall trend similar to that of disease prevalence ( Fig. 1 B). 3.2.2 Tuberculosis Unlike leprosy, although the ASPR of tuberculosis has shown an overall downward trend between 1990 and 2045, the number of cases fluctuated significantly, with some age groups showing an upward trend.

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