Outcome specific optimal systolic blood pressure targets in high risk patients, balancing cardiovascular benefits, renal risks, and cancer prevention: meta-analysis of randomised controlled trials.

Cancer and other safety outcomes We found a borderline significant reduction in the risk of cancer associated with the systolic blood pressure target of <120 mm Hg.

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In the diabetes specific trial populations, we saw a marginally significant interaction (P for interaction=0.06) for baseline glycaemic control, with a significant benefit in patients with HbA 1c ≤8.0% (random effects model: relative risk 0.74, 95% CI 0.64 to 0.87, P<0.05) ( table 1 ).

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