THROMBOTIC RISK EVALUATION OF TWO METHYLENETETRAHYDROFOLATE REDUCTASE MUTATIONS C677t AND A1298c IN VENOUS THROMBOEMBOLISM.

Acta Clin Croat · 2025 · PMC12863379 · PMID 41635665

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highly significantno p-value reported

In this study, we could not evaluate the combined effect of both mutations on VTE risk because there were no homozygous carriers of mutated alleles for C677T and A1298C due to already observed relatively low frequency of homozygous genotype of A1298C mutation (10.6%) and highly significant linkage disequilibrium between MTHFR C677T and MTHFR A1298C polymorphisms found in the Croatian population ( 26 ).

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