Transcriptomic and ultrastructural responses to Amiodarone-Itraconazole in naturally benznidazole-resistant and -susceptible Trypanosoma cruzi strains.

However, marked repression was observed across multiple metabolic pathways, primarily related to carbohydrate and complex lipid metabolism, including sphingolipid metabolism (fold enrichment = 2.54; p = 0.0103), fructose and mannose metabolism (fold enrichment = 5.95; p = 0.0026), and several pathways associated with glyconjugate biosynthesis (glycosphingolipids, O-type mucins, and GPI anchors), with fold enrichment values exceeding 8 and highly significant p-values (p < 0.005), indicating strong suppression of these biosynthetic functions.

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