We did indeed detect a highly significant relationship between mean expression level and likelihood of rhythmicity detection (Fig. 1E ), but the odds ratio for rhythmicity for GR-bound genes remained >1, even when expression level was taken into account, thus indicating that GR binding was marking a set of circadian rhythmic genes irrespective of gene expression.
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Glucocorticoid-dependence and independence of the circadian liver transcriptome.
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