Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function.

Nat Immunol · 2026 · PMC12864045 · PMID 41540267

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highly significantno p-value reported

We observed a striking elevation of transitional (10.4-fold) B cells, and milder but still highly significant increases in the numbers of naive (3.3-fold) and memory (2-fold) B cells, in pediatric, but not adult, participants (Fig. 3c ).

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