The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells.

EMBO J · 2026 · PMC12864753 · PMID 41408486

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highly significantno p-value reported

One sentinel SNV (rs3830303, chr3: 100,334,840:C/GC) showed a highly significant association with increased plasma αKGM ( P value 1.4 × 10 −36 ) (Chen et al, 2023 ).

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