Microglial low-affinity FcγR mediates the phagocytic elimination of dopaminergic neurons in Parkinson's disease degeneration.

NPJ Parkinsons Dis · 2026 · PMC12864834 · PMID 41545445

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In this set of experiments, following IFN-γ priming, canonically activated microglia significantly increased the expression of activation markers CD11b and F4/80, but most importantly, induced a highly significant increase in CD16/32, suggesting the production of FcγR to prepare for the phagocytic process (Fig. 5A, B ).

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