Machine learning-enabled spatial multi-omics uncovers lactate-driven targets and tumor microenvironmental reprogramming in cancer.

NPJ Digit Med · 2025 · PMC12864923 · PMID 41469480

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a decreasing trendno p-value reported

an increasing trendno p-value reported

Notably, in the high-lactate group, pyruvate levels showed a decreasing trend in monocytes/macrophages, T/NK cells, and epithelial cells, but an increasing trend in fibroblasts.

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