Pathologic evaluation of Syzygium aromaticum essential oil against pulmonary aspergillosis in non-neutropenic immunosuppressed rabbits.

In in vivo experiments, the findings related to CT scan images, lung tissue weight, bronchoalveolar lavage fluid and lung tissue fungal burden, and macroscopic and microscopic lung examination were very consistent, and an increasing trend was observed in the negative control group without receiving effective treatment, and a decreasing trend and improvement were observed in the groups treated with Itraconazole and different doses of clove essential oil in two time periods of 7 and 13 days post-inoculation to Aspergillus fumigatus strain ATCC 13,073, even though the changes sometimes were slight and differences might be scant between them.

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