Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines.

Front Mol Biosci · 2025 · PMC12865207 · PMID 41640602

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Second, Unfolded Protein Response (UPR) is also highly significant in both HT-29 and HCT116 cells, (NES 9.45 and 3.97, respectively)- six of eight significant DETs in Hallmark UPR in HT-29, all 5 UPR DETs in HCT116 are upregulated, indicating endoplasmic reticulum stress, which usually results from the accumulation of misfolded proteins, caused by oxidative stress.

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