Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system.

Reduction of PS in the backbone conferred a range of reduction in acute inhibition scores 3 h after ICV injection in mice, from complete abolition with ASO2, to highly significant reductions with ASO3 and ASO4, to no significant reduction with ASO8 (Fig. 5E ).

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