Molecular and cellular composition changes after neoadjuvant letrozole and palbociclib in early luminal breast cancer.

Cell Rep Med · 2026 · PMC12866096 · PMID 41519129

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highly significantno p-value reported

A highly significant increase in the proportions of naive (SELL+) and tissue-resident memory (CD69 + ) CD4 + T lymphocytes was observed, whereas there was a decrease in FOXP3+ regulatory T cells.

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almost significantno p-value reported

An almost significant BCSS benefit was observed in patients who achieved a low-ROR response with no events after a minimum per-protocol follow-up of 3 years (hazard ratio [HR] = 0.08; 95% CI, 0.005–1.43; p = 0.087; Figure 7 F).

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