Early Detection of Chemotherapy-Induced Glucose Metabolic Alterations in Bladder Carcinoma Using Deuterium (<sup>2</sup>H) Metabolic Imaging: in Vitro and in Vivo Assessments.

Although a decreasing trend in tumor glucose signal intensities was observed after treatment, only the 7.5 g kg −1 [2,3,4,6,6′‐ 2 H 5 ]‐glucose group showed a statistically significant reduction in signal intensities, from 4.44 ± 0.41 to 1.78 ± 0.42 ( P = 0.015, Figure 4H–N ).

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