NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1.

Adv Sci (Weinh) · 2026 · PMC12866834 · PMID 41388125

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[ 42 ] Thus, despite the normalization of NAD + /NADH ratios upon the deletion of one copy of SARM1, there are likely to be significant deficits in local NAD + homeostasis to perturb the purine and pyrimidine pathways in cKO;S null/+ , while complete SARM1 deletion ameliorates the deficits.

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