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Efficacy and Safety of Novel Botulinum Toxin Type A (Protoxin) in the Treatment of Moderate to Severe Glabellar Lines: A Multicenter, Randomized, Double-Blind, Active-Controlled Phase III Study.

Ann Dermatol · 2026 · PMC12868749 · PMID 41607140

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a decreasing trendno p-value reported
Both groups exhibited a decreasing trend in improvement rates over time, and the proportion of subjects with improvement at week 16 was under 20% in both groups.

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