M2 macrophages modulate the differentiation of CD8 + CD101-TIM3 + T cells via the SPP1‒CD44 pathway, influencing the immunotherapeutic response in NSCLC.

J Transl Med · 2026 · PMC12870260 · PMID 41495843

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a decreasing trendno p-value reported

In addition, a decreasing trend of SPP1 + TAMs in the TME has also been observed in NSCLC patients who responded well to immunotherapy [ 65 ].

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